Written for Synergy 3 (v3.8.4) and Synergy 1 (v1.22.3), checked 21 October 2026.
Hotkeys work in both apps when the computer whose keyboard and mouse you share runs Xorg instead of Wayland. To switch it, see: Switch back to Xorg on Ubuntu
This covers every hotkey, including the ones that lock the cursor to a computer and switch between computers: How to lock the cursor to a computer?
For what else differs on Wayland, see: Wayland support on Linux
What follows depends on your product: Synergy 3 or Synergy 1
Synergy 3
Synergy 3 (v3.8.4) has no hotkeys on a Wayland server, on any distro. On Wayland, hotkeys go through your desktop's global shortcuts portal, and Synergy 3's packages and its Flatpak carry their own copy of the portal library, from before it could do that, so a newer library on your system doesn't help. To use hotkeys, switch the primary computer to Xorg.
Synergy 1
Update to the latest Synergy 1 from the download page. From v1.21.2, Synergy 1 supports hotkeys on a Wayland server through your desktop's global shortcuts portal, when your distro's package was built with libraries new enough to have it. Your desktop may ask you to allow the shortcuts when the server starts; allow them, or the hotkeys won't work.
Those libraries are usually only in rolling distros such as Arch Linux, so on most other distros hotkeys on a Wayland server don't work yet, even when the rest of Synergy 1 does. The Flatpak carries its own older copy, so it doesn't support them; install the package for your distro instead. If hotkeys still don't work, switch the server computer to Xorg.